PROTAC LZK-IN-1

SKU: orb2945715

Description

PROTAC LZK-IN-1 (Compound 21A) is a degrader of leucine zipper kinase (LZK/MAP3K13). At 10 µM, it reduces LZK levels, downregulates p53 and c-Myc expression, and decreases viability in head and neck squamous cell carcinoma (HNSCC) cell lines, supporting its use in oncology research for in vitro mechanistic studies.

Research Area

Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2763268-64-8
• MW: 967.18
• Formula: C₅₁H₆₄F₂N₁₀O₅S
• SMILES: C([C@@H](NC(CCCCCCC(=O)N1CCC(CC1)C=2C=C(N=C(NC3=CC(C#N)=CC=N3)C2)N4CCC(F)(F)C4)=O)C(C)(C)C)(=O)N5[C@H](C(N[C@@H](C)C6=CC=C(C=C6)C7=C(C)N=CS7)=O)C[C@@H](O)C5
• Target: c-Myc,PROTACs,MDM-2/p53,MAP3K,MAPK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

162747707