PROTAC K-Ras Degrader-5

SKU: orb2802253

Description

Compound 69 is a cereblon-recruiting PROTAC that potently degrades pan-KRAS isoforms with a DC50 below 100 nM. This degrader demonstrates anticancer activity and serves as a valuable chemical tool for investigating KRAS biology in both cellular and in vivo cancer models.

Research Area

Cell Biology, Molecular Biology, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 3052745-16-8
• MW: 1025.17
• Formula: C₅₇H₆₃F₃N₁₀O₅
• SMILES: O=C1C2=CC=C(C(F)=C2CN1C3C(=O)NC(=O)CC3)N4CCC(CN5CCC(CC5)CC6CCN(CCOC7=NC8=C(F)C(=NC=C8C(=N7)N9CC%10NC(C9)CC%10)C=%11C=C(O)C=C%12C=CC(F)=C(C#C)C%12%11)CC6)CC4
• Target: PROTACs,DNA/RNA Synthesis,Ras

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172129049