PROTAC IRAK4 degrader-13

SKU: orb3136269

Description

PROTACIRAK4 degrader-13 (Degrader 1) is a selective IRAK4 PROTAC degrader, demonstrating DC50 values of 0.86 nM and 1.1 nM in monocytes and lymphocytes within PBMCs, respectively. It significantly induces TIR signaling activation and inhibits the expression of circulating pro-inflammatory cytokines in a psoriasis mouse model induced by Imiquimod. PROTACIRAK4 degrader-13 is applicable in the study of neutrophilic inflammatory diseases driven by TLR and IL-1R, such as hidradenitis suppurativa (HS) and atopic dermatitis (AD).

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 2432992-21-5
• MW: 843.94
• Formula: C₄₄H₅₂F₃N₉O₅
• SMILES: C(C1=C2C(N(C(=O)N2C)C3C(=O)NC(=O)CC3)=CC=C1)N4CCC(N(C[C@@H]5CC[C@H](CC5)N6C=C7C(=N6)C=C(C(C)(C)O)C(NC(=O)C=8N=C(C(F)(F)F)C=CC8)=C7)C)CC4
• Target: Interleukin,IRAK,PROTACs,TLR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Interleukin,IRAK,PROTACs,TLR