PROTAC HSP90 degrader BP3

SKU: orb1983417

Description

BP3 is a potent and selective CRBN-dependent PROTAC that degrades HSP90 with a DC50 of 0.99 µM in MCF-7 cells, inhibiting breast cancer cell proliferation. This tool compound is suitable for investigating HSP90 biology and targeted protein degradation in cancer research, both in vitro and in vivo.

Research Area

Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2669072-88-0
• MW: 641.08
• Formula: C₃₂H₂₉ClN₈O₅
• SMILES: O=C1C=2C=CC=C(NCCC#CC3=CN(C=4N=C(N=C(Cl)C34)N)CC5=NC=C(C(OC)=C5C)C)C2C(=O)N1C6C(=O)NC(=O)CC6
• Target: HSP,PROTACs

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

163196223