PROTAC HIF-1α degrader-2

SKU: orb3176972

Description

PROTACHIF-1αdegrader-2 is a highly efficient and selective PROTAC degrader targeting HIF-1α. It facilitates the degradation of HIF-1α via the ubiquitin-proteasome pathway by promoting the formation of the HIF-1α/VHL ternary complex. This compound inhibits the proliferation, migration, and colony formation of HeLa cells while inducing apoptosis (apoptosis). Additionally, PROTACHIF-1αdegrader-2 reduces the expression of p-MEK and p-AKT in the MAPK and PI3K/AKT pathways. It is useful for cervical cancer research.

Key Properties

• CAS Number: 3095636-64-6
• MW: 940.17
• Formula: C₅₀H₆₅N₇O₉S
• SMILES: C([C@@H](NC(CCCCCCCN1CCN(CC1)C2=CC=C(OCC(NC3=CC(C(OC)=O)=CC=C3O)=O)C=C2)=O)[C@](C)(C)C)(=O)N4[C@H](C(NCC5=CC=C(C=C5)C6=C(C)N=CS6)=O)C[C@@H](O)C4
• Target: PI3K,HIF/HIF Prolyl-Hydroxylase,Akt,p38 MAPK,PROTACs,Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PI3K,HIF/HIF Prolyl-Hydroxylase,Akt,p38 MAPK,PROTACs,Apoptosis