PROTAC GPX4 degrader-2

SKU: orb3133542

Description

PROTACGPX4 degrader-2 (compound 18a) is a proteolysis-targeting chimera (PROTAC) that targets the degradation of glutathione peroxidase 4 (GPX4), with a DC50, 48h value of 1.68 μM. It induces the accumulation of lipid peroxides and mitochondrial depolarization, subsequently triggering ferroptosis. Additionally, PROTACGPX4 degrader-2 exhibits antiproliferative activity.

Research Area

Cell Biology, Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• Formula: C₅₀H₆₁ClN₈O₉
• Target: Ferroptosis,Glutathione Peroxidase,PROTACs

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Ferroptosis,Glutathione Peroxidase,PROTACs