PROTAC FTO degrader 1

SKU: orb3175221

Description

PROTACFTO degrader 1 is a PROTAC designed to target and degrade fat mass and obesity-associated protein (FTO). It leverages the VHL E3 ligase and the ubiquitin-proteasome system for the selective degradation of FTO. This compound enhances m6A modifications on mRNAs related to ribosome biogenesis and promotes their YTHDF2-mediated degradation. Furthermore, PROTACFTO degrader 1 effectively inhibits cancer cell proliferation and induces apoptosis, making it a valuable candidate for cancer research, particularly in acute myeloid leukemia (AML).

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology, Pharmacology & Drug Discovery, Protein Biochemistry

Key Properties

• Target: Apoptosis,Caspase,PARP,PROTACs

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Apoptosis,Caspase,PARP,PROTACs