PROTAC EZH2 Degrader-3

SKU: orb2695596

Description

PROTAC EZH2 Degrader-3 (ZJ-20) is a potent, cell-permeable small molecule that selectively degrades EZH2 and disrupts PRC2 complex function, reducing H3K27me3 levels. It demonstrates robust anti-proliferative effects in vitro by inducing G0/G1 cell cycle arrest and apoptosis, making it a valuable chemical probe for oncology and epigenetics research.

Research Area

Cell Biology, Epigenetics & Chromatin, Pharmacology & Drug Discovery

Key Properties

• MW: 981.19
• Formula: C₅₆H₆₈N₈O₈
• SMILES: O=C1NC(=O)C=2C1=C3C4=CC(=CC=C4NC3=C5C2CCC5)C(=O)CCC(=O)O
• Target: Histone Methyltransferase,PROTACs,Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

57399257