PROTAC ERα Degrader-8

SKU: orb2565419

Description

PROTAC ERα Degrader-8 (compound ii-56) is a potent, small-molecule degrader of the estrogen receptor alpha (ERα), demonstrating high cellular potency with a DC50 of 6 pM in MCF7 breast cancer cells. This tool compound is valuable for investigating targeted protein degradation in ER+ breast cancer models, both in vitro and in vivo.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 3025533-68-7
• MW: 749.94
• Formula: C₄₇H₅₁N₅O₄
• SMILES: OC=1C=C2C([C@@H]([C@@H](CC2)C3=CC=CC=C3)C4=CC=C(C=C4)N5C6(CC(CN7CCN(CC7)C=8C=C9C(=CC8)C(=O)N(C9)[C@@H]%10C(=O)NC(=O)CC%10)CC5(CC6)[H])[H])=CC1
• Target: Estrogen Receptor/ERR,PROTACs

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

171038211