PROTAC ERα Degrader-7

SKU: orb2565420

Description

PROTAC ERα Degrader-7 (i-320) is a potent, heterobifunctional degrader of estrogen receptor alpha (ERα) with a DC50 of 6 pM. It employs a cereblon-binding ligand linked to an ERα-targeting moiety, facilitating the ubiquitination and proteasomal degradation of ERα. This tool compound is valuable for investigating ERα biology and therapeutic strategies in breast cancer research, both in vitro and in vivo.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 3025781-93-2
• MW: 773.91
• Formula: C₄₆H₄₉F₂N₅O₄
• SMILES: FC1(F)C[C@@H]([C@@H](C=2C1=CC(O)=CC2)C3=CC=C(C=C3)N4CCC(CN5CCN(CC5)C=6C=C7C(=CC6)C(=O)N(C7)[C@@H]8C(=O)NC(=O)CC8)CC4)C9=CC=C(C)C=C9
• Target: PROTACs,Estrogen Receptor/ERR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

170706247