PROTAC EGFR degrader 6

SKU: orb1982861

Description

PROTAC EGFR degrader 6 is a potent, cell-permeable compound that selectively degrades EGFR Del19 with a DC50 of 45.2 nM in HCC827 cells. It induces cell cycle arrest at the G1 phase and promotes apoptosis, making it a valuable chemical tool for studying EGFR-driven oncogenesis and targeted protein degradation in cancer research.

Research Area

Cardiovascular Research, Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2409793-28-6
• MW: 913.05
• Formula: C₄₉H₅₇FN₁₂O₅
• SMILES: OCC1CCN(CC1)c1nc(Nc2ccc(F)cc2)nc2cnc(Nc3ccc(cn3)N3CCN(CCCCCCCC(=O)Nc4cccc5C(=O)N(Cc45)C4CCC(=O)NC4=O)CC3)cc12
• Target: Apoptosis,Others,PROTACs,EGFR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

162667990