PROTAC EGFR degrader 10

SKU: orb2564420

Description

PROTAC EGFR degrader 10 (Compound B56) is a cereblon-directed bifunctional molecule that potently degrades EGFR, FAK, and RSK1 with a DC50 below 100 nM. It demonstrates potent anti-proliferative activity in cellular models, including BaF3 cells harboring EGFR mutations, supporting its use in targeted protein degradation research for oncology.

Research Area

Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 3034244-56-6
• MW: 973.62
• Formula: C₄₉H₆₅ClN₁₀O₇S
• SMILES: O=C1NC(=O)C(C2=CC=C(C=C2)N3CCC(OCCN4CCN(CC4)C5CCN(C6=CC(OC)=C(C=C6CC)NC7=NC=C(Cl)C(=N7)NC8=CC=C(OC)C=C8N(C)S(=O)(=O)C)CC5)CC3)CC1
• Target: FAK,EGFR,PROTACs

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

171491397