PROTAC EGFR degrader 5

SKU: orb1982862

Description

PROTAC EGFR Degrader 5 (Compound 10) is a potent and selective degrader of EGFR Del19, demonstrating a DC50 of 34.8 nM in HCC827 cells. This small molecule induces apoptosis and G1 phase cell cycle arrest, supporting its use in targeted protein degradation research for oncology, both in vitro and in vivo.

Research Area

Cardiovascular Research, Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2409793-36-6
• MW: 1070.33
• Formula: C₅₇H₇₂FN₁₃O₅S
• SMILES: Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCN2CCN(CC2)c2ccc(Nc3cc4c(nc(Nc5ccc(F)cc5)nc4cn3)N3CCC(CO)CC3)nc2)C(C)(C)C)cc1
• Target: Apoptosis,Others,EGFR,PROTACs

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

162669709