PROTAC EGFR degrader 11

SKU: orb2564616

Description

PROTAC EGFR degrader 11 (Compound B71) is a potent CRBN-based degrader with a DC50 <100 nM for EGFR, also degrading FAK and RSK1. It inhibits proliferation of BaF3 cells (IC50 <100 nM), supporting its use in targeted protein degradation research for oncology, both in vitro and in vivo.

Research Area

Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 3034244-71-5
• MW: 991.61
• Formula: C₄₉H₆₄ClFN₁₀O₇S
• SMILES: O=C1NC(=O)C(C2=CC=C(C=C2F)N3CCC(OCCN4CCN(CC4)C5CCN(C6=CC(OC)=C(C=C6CC)NC7=NC=C(Cl)C(=N7)NC8=CC=C(OC)C=C8N(C)S(=O)(=O)C)CC5)CC3)CC1
• Target: EGFR,PROTACs,FAK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

171491423