PROTAC c-Met Degrader-4

SKU: orb3177198

Description

PROTACc-Met Degrader-4 (compound D15) is a potent and orally active PROTACc-MET degrader. It demonstrates exceptional intracellular degradation activity with a DC50 of less than 0.5 nM. This compound can induce cell cycle arrest and apoptosis (apoptosis), inhibit cell invasion and migration, thereby suppressing cell proliferation. It also inhibits the growth of Hs746T xenograft tumors in nude mice. PROTACc-Met Degrader-4 is applicable in cancer research, including studies on non-small cell lung cancer and gastric cancer.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2959535-15-8
• MW: 860.93
• Formula: C₄₇H₄₄N₁₀O₇
• SMILES: N#CC1=CC=CC(=C1)C2=NN(C(=O)C=C2)CC3=CC=CC(=C3)C4=NC=C(OCC5CCN(CC(=O)N6CCN(C7=CC=C8C(=O)N(C(=O)C8=C7)C9C(=O)NC(=O)CC9)CC6)CC5)C=N4
• Target: PROTACs,c-Met/HGFR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PROTACs,c-Met/HGFR