PROTAC c-Met degrader-3

SKU: orb2944527

Description

PROTACc-Met degrader-3 (Compound 22b) is a potent, cell-permeable c-Met degrader with a DC50 of 0.59 nM in EBC-1 lung cancer cells. It facilitates targeted ubiquitination and proteasomal degradation of c-Met, making it a valuable chemical tool for investigating c-Met-dependent signaling in lung cancer research, both in vitro and in vivo.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• MW: 919.037
• Formula: C₅₁H₅₄N₁₀O₇
• SMILES: COC1=C(C=C(C=C1)C(=O)N2CCC3(CCN(CC3)C(=O)CN4CCC(CC4)COC5=CN=C(N=C5)C6=CC=CC(=C6)CN7C(=O)C=CC(=N7)C8=CC=CC(=C8)C#N)CC2)N9CCC(=O)NC9=O
• Target: PROTACs,c-Met/HGFR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172676894