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PROTAC BTK Degrader-13

SKU: orb2945030

Description

PROTAC BTK Degrader-13 is a bifunctional degrader that potently depletes BTK (DC50=0.27 µM) and inhibits its kinase activity (IC50=0.44 µM). It also suppresses ITK and p38 MAPK, blocking BCR signaling, making it a useful chemical probe for studying B-cell malignancies and autoimmune disorders in vitro.

Research Area

Cardiovascular Research, Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

Key Properties

MW622.63
FormulaC33H30N6O7
TargetTyrosine Kinases,BTK,PROTACs,p38 MAPK

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Protocol Information