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PROTAC BRD4 Degrader-41

SKU: orb3176815

Description

PROTACBRD4 Degrader-41 (Compound A5) is a BRD4 PROTAC degrader with a DC50 of 0.97 nM. It exhibits potent antiproliferative activity against various cancer cells, including AML, lymphoma, breast cancer, ovarian cancer, and non-small cell lung cancer. The compound induces G0/G1 phase arrest and apoptosis in MV4-11 cells and downregulates c-Myc transcription levels.

Research Area

Cell Biology, Epigenetics & Chromatin, Pharmacology & Drug Discovery

Images & Validation

Key Properties

Targetc-Myc,PROTACs,Apoptosis,Epigenetic Reader Domain

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Protocol Information