PROTAC BET Degrader-15

SKU: orb3210062

Description

PROTAC BET Degrader-15 is a BET PROTAC degrader, with DC50 values of less than 0.10 nM, less than 0.01 nM, and less than 0.01 nM for BRD2, BRD3, and BRD4 respectively. It induces significant G2/M phase cell cycle arrest and triggers apoptosis. Additionally, PROTAC BET Degrader-15 leads to notable downregulation of c-Myc, while upregulating cell cycle inhibitor p21, downregulating CDK6, and increasing the apoptosis marker cleaved PARP. This compound is applicable to the study of hematologic malignancies and lung cancer.

Key Properties

• Target: Epigenetic Reader Domain,CDK,c-Myc,PARP,PROTACs,Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Epigenetic Reader Domain,CDK,c-Myc,PARP,PROTACs,Apoptosis