PROTAC Bcl-xL degrader-4

SKU: orb3136717

Description

PROTACBcl-xL degrader-4 (Compound 2-38-III) is a Bcl-xL PROTAC degrader with significant antitumor activity against HepG2 and HUVEC cells. It induces apoptosis by reducing mitochondrial membrane potential and activating the MAPK signaling pathway. PROTACBcl-xL degrader-4 markedly inhibits tumor growth in xenograft mouse models.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2930759-37-6
• MW: 702.71
• Formula: C₃₉H₃₄N₄O₉
• SMILES: O=C(OCCOCCOCCNC1=CC=CC=2C(=O)N(C(=O)C12)C3C(=O)NC(=O)CC3)C4=CC=C5NC(=CC(=O)C5=C4)C=6C=CC=C7C=CC=CC76
• Target: PROTACs,ROS,ERK,p38 MAPK,Apoptosis,Bcl-2 Family,JNK,Mitochondrial Metabolism

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PROTACs,ROS,ERK,p38 MAPK,Apoptosis,Bcl-2 Family,JNK,Mitochondrial Metabolism