PROTAC ATR degrader-2

SKU: orb2565426

Description

PROTAC ATR degrader-2 (Compound 8i) is a potent and selective ATR degrader with DC50 values of 22.9 nM and 34.5 nM in MV-4-11 and MOLM-13 AML cell lines, respectively. It induces apoptosis, inhibits proliferation, and demonstrates favorable pharmacokinetics and antitumor efficacy in an AML mouse model, supporting its use in oncology and targeted protein degradation research.

Research Area

Cell Biology, Epigenetics & Chromatin, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 3010273-12-5
• MW: 743.81
• Formula: C₄₀H₄₁N₉O₆
• SMILES: N(C(CCCCN1CCN(C(=O)C2=CC=C(C=C2)C3=NC(C(NC4=CC=CC=C4)=O)=C(N)N=C3)CC1)=O)C5=C6C(C(=O)N(C6)C7C(=O)NC(=O)CC7)=CC=C5
• Target: PROTACs,Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

171714318