PROTAC AR Degrader-12

SKU: orb3176015

Description

PROTACAR Degrader-12 is an effective PROTAC that targets the androgen receptor (AR) co-activator binding site (AR-CBS). It induces AR degradation via the ubiquitin-proteasome system (UPS) pathway, inhibiting tumor cell growth by affecting DNA replication and cell division. Besides effectively degrading AR, it strongly inhibits the proliferation of MCF-7 cells and various mutant or drug-resistant breast cancer cells. PROTACAR Degrader-12 blocks the estrogen receptor α (ERα) signaling pathway through dual mechanisms of ERα protein downregulation and transcriptional activity inhibition, significantly suppressing mRNA expression of FOXA1, GREB1, SRC, and PELP1. It is applicable in breast cancer research.

Research Area

Cardiovascular Research, Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• Target: Src,Androgen Receptor,PROTACs,Estrogen Receptor/ERR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Src,Androgen Receptor,PROTACs,Estrogen Receptor/ERR