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PROTAC ALK degrader-4

SKU: orb3175469

Description

PROTACALK degrader-4 (Compound B8) is an ALKPROTAC degrader with a DC50 of 445.25 nM. It demonstrates significant antiproliferative activity against NCI-H2228 and NCI-H3122 cell lines. This compound causes a substantial downregulation of 390 proteins, including IGF-1R and its downstream proteins, such as ERK1/2 and STAT3. PROTACALK degrader-4 is applicable in lung adenocarcinoma research.

Images & Validation

Key Properties

TargetALK,STAT,PROTACs,ERK,IGF-1R

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information