Prostratin

SKU: orb1705054

Description

Prostratin is a potent, orally bioavailable PKC activator (Ki=12.5 nM) that induces NF-κB and HIV expression. It exhibits anti-leukemic activity by inhibiting AML cell growth and enhancing cytarabine-induced differentiation, and it suppresses KRAS-mutated tumor growth through KRAS phosphorylation.

Research Area

Epigenetics & Chromatin, Infectious Disease & Virology, Pharmacology & Drug Discovery, Protein Biochemistry, Signal Transduction

Key Properties

• CAS Number: 60857-08-1
• MW: 390.47
• Formula: C₂₂H₃₀O₆
• SMILES: O(C(C)=O)[C@@]12[C@@](C1(C)C)([C@]3([C@](O)([C@H](C)C2)[C@]4([C@](O)(CC(CO)=C3)C(=O)C(C)=C4)[H])[H])[H]
• Target: NF-κB,Ras,PKC,HIV Protease,Kras

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

454217