Prostratin

SKU: orb1705054

Description

Prostratin is a potent, orally bioavailable PKC activator (Ki=12.5 nM) that induces NF-κB and HIV expression. It exhibits anti-leukemic activity by inhibiting AML cell growth and enhancing cytarabine-induced differentiation, and it suppresses KRAS-mutated tumor growth through KRAS phosphorylation.

Research Area

Neuroscience

Key Properties

• CAS Number: 60857-08-1
• MW: 390.47
• Purity: >98%
• Formula: C₂₂H₃₀O₆
• SMILES: [H][C@]12[C@]3([H])C=C(CO)C[C@]4(O)C(=O)C(C)=C[C@@]4([H])[C@@]3(O)[C@H](C)C[C@@]1(OC(C)=O)C2(C)C
• Target: Kinase
• Solubility: Soluble in DMSO (up to 30 mg/ml).

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

12-Deoxyphorbol 13-Acetate; dPAc

Compound Identifiers

PubChem CID

454217