Prolyl-4-hydroxylase Inhibitor 11

SKU: orb1741453

Description

2,2'-Bipyridine-5,5'-dicarboxylic acid

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1802-30-8
• MW: 244.2
• Purity: 99.76% (May vary between batches)
• Formula: C₁₂H₈N₂O₄
• SMILES: OC(=O)c1ccc(nc1)-c1ccc(cn1)C(O)=O
• Target: Others
• Solubility: DMSO:0.97 mg/mL (3.97 mM)

Bioactivity

• Target IC50:
  Prolyl hydroxylase:0.19 microM
• In Vivo:
  In this study, we evaluated the role of 2,2'-bipyridine-5,5'-dicarboxylic acid (Bpy-COOH) in protecting Chlorella vulgaris from the oxidative stress and toxicity induced by Cu(II). The in vivo experiments showed that the production of reactive oxygen species in C. pyrenoidosa treated by the addition of Bpy-COOH and Cu(II) in three orders were all significantly less than that in cases treated with only Cu(II).
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• In Vitro:
  In this study, we evaluated the role of 2,2'-bipyridine-5,5'-dicarboxylic acid (Bpy-COOH) in protecting Chlorella vulgaris from the oxidative stress and toxicity induced by Cu(II). In vitro tests indicated that peroxidase-like complexes could be formed between Bpy-COOH and Cu(II). It could be concluded that the use of Bpy-COOH could significantly decrease Cu(II) toxicity to algal cells by forming peroxidase-like complexes. Members of a series of 2,2'-bipyridines have been synthesized and tested as inhibitors of prolyl hydroxylase. [2,2'-bipyridine]-5,5'-dicarboxylic acid (IC50 = 0.19 microM) is the most potent inhibitor of its type yet reported.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Proline 4-hydroxylase

Compound Identifiers

PubChem CID

192744