Progerinin

SKU: orb2695236

Description

Progerinin (SLC-D011) is an orally bioavailable small molecule inhibitor of the progerin-lamin A interaction. It is used in HGPS research to ameliorate nuclear abnormalities and cellular senescence in both in vitro and in vivo models, facilitating the study of this premature aging syndrome.

Key Properties

• CAS Number: 2249696-72-6
• MW: 362.42
• Formula: C₂₃H₂₂O₄
• SMILES: CC1(C)OC=2C(=CC3=C(C2)OC(=O)C=C3)C[C@@H]1OC/C=C/C4=CC=CC=C4
• Target: Others

Bioactivity

• In Vivo:
  In LmnaG609G/G609G mice, intraperitoneal injection of Progerinin (20 mg/kg, twice weekly) increased body weight and extended lifespan to 21 weeks; oral administration (50 mg/kg, once daily) also increased body weight and prolonged lifespan .
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• In Vitro:
  In HGPS patient-derived fibroblasts (e.g., AG11498), Progerinin (100 nM, 3 days) significantly reduced progerin expression and induced the expression of H3K9me3 and cell cycle protein Cyclin B1 . In various HGPS cells (e.g., AG11513, AG11498), Progerinin (2 μM, 7 days) decreased progerin and p16/INK4A expression while increasing H3K9me3 levels .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SLCD011, SLC-D011

Compound Identifiers

PubChem CID

46220467