Procyanidin A1

SKU: orb1297534

Description

Procyanidin A1 is a proanthocyanidin with demonstrated antiallergic properties. It suppresses mast cell degranulation in RBL-2H3 cells by inhibiting signaling downstream of PKC activation and internal calcium mobilization. This compound is a useful research tool for studying allergic response mechanisms in vitro.

Research Area

Epigenetics & Chromatin, Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 103883-03-0
• MW: 576.50
• Purity: 99.52% (May vary between batches)
• Formula: C₃₀H₂₄O₁₂
• SMILES: OC1Cc2c(O)cc3OC4(Oc5cc(O)cc(O)c5C(C4O)c3c2OC1c1ccc(O)c(O)c1)c1ccc(O)c(O)c1
• Target: PKC,LDL,Calcium Channel
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2.00 mg/mL (3.47 mM);DMSO:55.00 mg/mL (95.40 mM)

Bioactivity

• In Vitro:
  We found that a peanut-skin extract (PSE) inhibits the degranulation induced by antigen stimulation of rat basophilic leukemia (RBL-2H3) cells. A low-molecular-weight fraction from PSE, PSEL, also had inhibitory activity against allergic degranulation. A main polyphenol in PSEL was purified by gel chromatography and fractionated by YMC-gel ODS-AQ 120S50 column. Electrospray ionization mass spectrometry (ESI-MS) analysis of the purified polyphenol gave m/z 599 [M+Na] . Based on the results of 1H-NMR, 13C-NMR spectra, and optical rotation analysis, the polyphenol was identified as Procyanidin A1. It inhibited the degranulation caused by antigen stimulation at the IC50 of 20.3 μM. Phorbol-12-myristate-13-acetate (PMA) and 2,5,-di(tert-butyl)-1,4-hydroquinone (DTBHQ)-induced processes of degranulation were also inhibited by Procyanidin A1

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Calcium Channel, CalciumChannel, LDL, inhibit, Inhibitor, Protein kinase C, PKC, Procyanidin A 1, Procyanidin A1, Procyanidin A-1, Proanthocyanidin A 1, Proanthocyanidin A1, Proanthocyanidin A-1

Compound Identifiers

PubChem CID

5089889