Procaine

SKU: orb1311006

Description

Procaine

Research Area

Cell Biology, Epigenetics & Chromatin, Infectious Disease & Virology, Molecular Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 59-46-1
• MW: 236.31
• Purity: 99.55% (May vary between batches)
• Formula: C₁₃H₂₀N₂O₂
• SMILES: CCN(CCOC(C1=CC=C(C=C1)N)=O)CC
• Target: Histone Demethylase|||DNA/RNA Synthesis|||Sodium Channel
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:47 mg/mL (198.89 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.46 mM);Ethanol:43 mg/mL (181.96 mM)

Bioactivity

• In Vivo:
  Procaine has a growth-inhibitory and demethylating effect against xenograft in vivo.
• In Vitro:
  The viability of HLE, HuH7, and HuH6 cells is significantly decreased by procaine treatment. Inhibition of S/G2/M transition, morphological changes such as vacuolation and no increase in apoptosis rate are observed in the procaine-treated HLE cells. All the genes transcriptionally suppressed by DNA hypermethylation are demethylated and reactivated with procaine treatment. Procaine has growth-inhibitory and demethylating effects on human hepatoma cells.
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• Cell Research:
  For apoptosis analysis, the TUNEL assay is performed on HLE cells treated with no drug(control), or 1 μM of DAC(5-aza-2'-deoxycytidine), or 1 mM of PCA(procaine), or 1 mM of PCAA(procainamide) for 96 h. The proportion of TUNEL-positive cells was calculated by counting at least 500 cells randomly. All assays were carried out in triplicate. (Only for Reference)
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

multiple, inhibit, Inhibitor, Novocaine, onset, Histone Demethylase, HistoneDemethylase, DNASynthesis, DNA/RNA Synthesis, DNA Synthesis, Duracaine, duration, Procaine, targets, RNASynthesis, RNA Synthesis, Sodium Channel, SodiumChannel, Spinocaine, Vitamin H3

Compound Identifiers

PubChem CID

4914