[Pro18, Asp21] β - Amyloid (17 - 21), iAb5

SKU: orb2693322

Description

[Pro18, Asp21] β - Amyloid (17 - 21), iAb5 is a potent degrader of cerebral amyloid-beta (Abeta). Abeta deposition is associatied with the Alzheimer disease (AD), due to its related toxicity linked to its beta-sheet conformation and/or aggregation. β-Sheet Breaker Peptide iAβ5 reproducibly induces in vivo disassembly of fibrillar amyloid deposits. Thus, [Pro18, Asp21] β - Amyloid (17 - 21), iAb5 prevents and/or reverses neuronal shrinkage caused by Abeta, and reduces the extent of interleukin-1beta positive microglia-like cells that surround the Abeta deposits. β-Sheet Breaker Peptide iAβ5 reduces the size and/or number of cerebral amyloid plaques in AD. [Pro18, Asp21] β - Amyloid (17 - 21), iAb5 labeled by hydrophobic benzyl alcohol (HBA) tag, can be used for quantitative assay by showing vivid blue color under acidic conditions.

Research Area

Neuroscience; Cell Biology

Key Properties

• Target: Amyloid-β
• CAS Number: 182912-74-9
• MW: 637.74
• Purity: ≥95%
• Formula: C₃₃H₄₃N₅O₈
• Protein Sequence: LPFFD

Storage & Handling

• Expiration Date: 6 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Amyloid-β