[Pro18, Asp21] β - Amyloid (17 - 21), iAb5

• Catalog Number: orb2693322
• Category: Proteins
• Description: [Pro18, Asp21] β - Amyloid (17 - 21), iAb5 is a potent degrader of cerebral amyloid-beta (Abeta). Abeta deposition is associatied with the Alzheimer disease (AD), due to its related toxicity linked to its beta-sheet conformation and/or aggregation. β-Sheet Breaker Peptide iAβ5 reproducibly induces in vivo disassembly of fibrillar amyloid deposits. Thus, [Pro18, Asp21] β - Amyloid (17 - 21), iAb5 prevents and/or reverses neuronal shrinkage caused by Abeta, and reduces the extent of interleukin-1beta positive microglia-like cells that surround the Abeta deposits. β-Sheet Breaker Peptide iAβ5 reduces the size and/or number of cerebral amyloid plaques in AD. [Pro18, Asp21] β - Amyloid (17 - 21), iAb5 labeled by hydrophobic benzyl alcohol (HBA) tag, can be used for quantitative assay by showing vivid blue color under acidic conditions.
• Target: Amyloid-β
• Purity: ≥95%
• Protein Sequence: LPFFD
• MW: 637.74
• Solubility (25°C): Water: 50 mg/mL
• CAS Number: 182912-74-9
• Formula: C₃₃H₄₃N₅O₈
• Note: For research use only