Pro-PEG3-BA

SKU: orb3177222

Description

Pro-PEG3-BA is a PROTAC degrader targeting EML4-ALK and EGFR, effectively degrading EML4-ALK and EGFR mutants (L858R/T790M) with DC50 values of 0.42 μM and 13.50 μM, respectively. In vitro, it inhibits the proliferation of non-small cell lung cancer cells, inducing cell cycle arrest and apoptosis. Pro-PEG3-BA demonstrates favorable safety characteristics and can reduce EML4-ALK protein expression by modulating the ubiquitin-proteasome system in vivo, making it suitable for research on non-small cell lung cancer.

Research Area

Cardiovascular Research, Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 3057939-64-4
• MW: 787.3
• Formula: C₃₇H₅₂ClN₈O₇P
• SMILES: O(C)C=1C=C(C=CC1NC=2N=C(NC3=C(P(C)(C)=O)C=CC=C3)C(Cl)=CN2)N4CCN(C(CCOCCOCCOCCNC(=O)[C@@H]5CCCN5)=O)CC4
• Target: PROTACs,EGFR,Apoptosis,ALK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PROTACs,EGFR,Apoptosis,ALK