pro-FTY

SKU: orb3135717

Description

pro-FTY is an anticancer prodrug of FTY720 and acts as a sphingosine-1-phosphate (S1P) inhibitor. It specifically inhibits S1P signaling in cancer cells via a drug delivery system (DDS) that reacts with acrolein. pro-FTY significantly reduces the survival of breast cancer cells, including multidrug-resistant cells and organoids resistant to Paclitaxel or Doxorubicin. Additionally, pro-FTY effectively suppresses tumor growth in xenograft mouse models of 4T1 cells or organoids while avoiding lymphopenia.

Research Area

Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 3064707-13-4
• MW: 566.77
• Formula: C₃₃H₅₀N₄O₄
• SMILES: [N-]=[N+]=NC=1C(=CC(=CC1C(C)C)COC(=O)NC(CO)(CO)CCC2=CC=C(C=C2)CCCCCCCC)C(C)C
• Target: STAT,LPL Receptor

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

STAT,LPL Receptor