PRMT5-MTA-IN-8

SKU: orb3210381

Description

PRMT5-MTA-IN-8 is an orally active inhibitor of the PRMT5-MTA complex with an IC50 of 4.4 nM. It effectively inhibits the production of symmetric dimethylarginine (SDMA) within cells and suppresses the proliferation of MTAP-deficient cells. In a mouse model of triple-negative breast cancer, PRMT5-MTA-IN-8 demonstrates antitumor efficacy by inhibiting PRMT5, reducing SDMA levels, and inducing tumor cell apoptosis (Apoptosis). This compound is applicable for research in cancers such as triple-negative breast cancer.

Key Properties

• CAS Number: 3105952-57-3
• MW: 441.28
• Formula: C₁₉H₁₇BrN₆O₂
• SMILES: O=C(C=1C=CC=2N=C(N)C=3C=NN(C3C2C1)C)N(OC)CC4=NC=C(Br)C=C4
• Target: Histone Methyltransferase,Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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Gene Symbol

Histone Methyltransferase,Apoptosis