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PRMT5-MTA-IN-7

SKU: orb3174899

Description

PRMT5-MTA-IN-7 (Compound 14) is a selective inhibitor of PRMT5-MTA. It exhibits KD values of 236 nM for PRMT5-MTA and 2.84 μM for PRMT5-SAM, with IC50 values of 4.08 μM and 13.6 μM, respectively. PRMT5-MTA-IN-7 selectively inhibits the proliferation of MTAP-deficient cancer cells and is applicable in colon cancer research.

Research Area

Epigenetics & Chromatin

Images & Validation

Key Properties

CAS Number303969-88-2
MW376.43
FormulaC17H20N4O4S
SMILESCN1C2=C(N(CC3=CC=C(C)C=C3)C(SCC(O)CO)=N2)C(=O)NC1=O
TargetHistone Methyltransferase

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information