PRMT5-MTA-IN-5

SKU: orb3135700

Description

PRMT5-MTA-IN-5 (Compound 7) is an orally active, irreversible inhibitor of the PRMT5-MTA complex (PRMT5•MTA) with an IC50 value of 1.15 nM. It effectively blocks arginine methylation, impedes the processing of ribosomal RNA, and suppresses the expression of proteins related to the cell cycle. PRMT5-MTA-IN-5 significantly inhibits the proliferation of tumor cells lacking MTAP and shows potential for research into MTAP-deficient solid tumors, such as liver, breast, and pancreatic cancers.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 3078322-88-7
• MW: 481.52
• Formula: C₂₇H₂₄FN₇O
• SMILES: N#CC=1C(=C(F)C(=CC1N2CC(=C)C2)C)C3=C(C=NN3C)C=4C=C(C=C)C=5C(=O)NN=C(C5C4)CN
• Target: Histone Methyltransferase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Histone Methyltransferase