PRMT5-MTA-IN-3

SKU: orb3028661

Description

PRMT5-MTA-IN-3 (Compound P2A) is an orally active and selective inhibitor of protein arginine methyltransferase 5 (PRMT5). It inhibits the proliferation of MTAP-deficient colorectal cancer HCT-116 cell line with an IC50 value of 5 nM. PRMT5-MTA-IN-3 holds potential for research in cancers, particularly in MTAP-deficient tumors such as colorectal cancer, non-small cell lung cancer, and pancreatic cancer.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 3028674-29-2
• MW: 434.372
• Formula: C₁₉H₁₇F₃N₆O₃
• SMILES: N(C(C(NC1=C2C(N(C)N=C2)=C(N)N=C1)=O)=O)(C)[C@H]3C=4C(=CC(C(F)(F)F)=CC4)OC3
• Target: Histone Methyltransferase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Histone Methyltransferase