PRMT5-MTA-IN-1

SKU: orb3134855

Description

PRMT5-MTA-IN-1 (Compound A9a) is an inhibitor of the protein arginine methyltransferase PRMT5-MTA. It suppresses the proliferation of colorectal cancer cells HCT116, both wild-type and MTAP del mutants, with IC50 values of 16 nM and 2.47 μM, respectively. Additionally, PRMT5-MTA-IN-1 demonstrates favorable hepatic microsomal stability, membrane permeability, and pharmacokinetic properties in CD-1 mice.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 3048425-88-0
• MW: 449.40
• Formula: C₂₂H₁₉F₄N₃O₃
• SMILES: CC=1C2=C(N=C(N)C1CO)C=C(F)C(C(N(C)[C@H]3C=4C(OC3)=CC(C(F)(F)F)=CC4)=O)=C2
• Target: Histone Methyltransferase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Histone Methyltransferase