PRMT1-IN-3

SKU: orb3173268

Description

PRMT1-IN-3 is a potent inhibitor of protein arginine methyltransferase 1 (PRMT1) with an IC50 of 4.11 μM. It also inhibits PRMT6 and PRMT8, with IC50 values of 23.3 and 30.1 μM, respectively. In triple-negative breast cancer (TNBC) cells, PRMT1-IN-3 reduces asymmetric dimethylarginine (ADMA) levels and the histone modification H4R3me2a. It induces cell cycle arrest and apoptosis in MDA-MB-231 cells and inhibits cell migration and colony formation. Furthermore, PRMT1-IN-3 serves as a chemosensitizer for Paclitaxel and is applicable in TNBC research.

Research Area

Cell Biology, Epigenetics & Chromatin

Key Properties

• CAS Number: 892570-48-8
• MW: 302.39
• Formula: C₁₈H₂₃FN₂O
• SMILES: FC1=CC=C(C=C1)COC=2C=CC=CC2CNCCCNC
• Target: Apoptosis,Histone Methyltransferase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Apoptosis,Histone Methyltransferase