PRI-724

SKU: orb1223869

Description

PRI-724 (PRI724) is a potent, specific, second generation CBP/beta-catenin antagonist with IC50 of 150 nM, an isomer or enantiomer of ICG-001; binds specifically to the co-activator CBP, but not to p300; selectively induce apoptosis in colon carcinoma cells but not in normal colon cells, and exhibits antitumor activity in the mouse xenograft models of colon cancer.Blood Cancer Phase 2 Clinical.

Key Properties

• CAS Number: 847591-62-2
• MW: 548.63
• Purity: >98% (HPLC)
• Formula: C₃₃H₃₂N₄O₄
• SMILES: C1CN([C@H]2CN(C(=O)[C@@H](N2C1=O)CC3=CC=C(C=C3)O)CC4=CC=CC5=CC=CC=C54)C(=O)NCC6=CC=CC=C6
• Target: Beta-catenin
• Solubility: DMSO: 54.9 mg/mL (100 mM)；Ethanol: 27.4 mg/mL (50 mM) （ < 1 mg/ml refers to the product slightly soluble or insoluble )

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PRI 724 | PRI724

Quick Database Links

Gene Symbol

Beta-catenin