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PRI-724

SKU: orb1223869

Description

PRI-724 (PRI724) is a potent, specific, second generation CBP/beta-catenin antagonist with IC50 of 150 nM, an isomer or enantiomer of ICG-001; binds specifically to the co-activator CBP, but not to p300; selectively induce apoptosis in colon carcinoma cells but not in normal colon cells, and exhibits antitumor activity in the mouse xenograft models of colon cancer.Blood Cancer Phase 2 Clinical.

Images & Validation

Key Properties

CAS Number847591-62-2
MW548.63
Purity>98% (HPLC)
FormulaC33H32N4O4
SMILESC1CN([C@H]2CN(C(=O)[C@@H](N2C1=O)CC3=CC=C(C=C3)O)CC4=CC=CC5=CC=CC=C54)C(=O)NCC6=CC=CC=C6
TargetBeta-catenin
SolubilityDMSO: 54.9 mg/mL (100 mM);Ethanol: 27.4 mg/mL (50 mM) ( < 1 mg/ml refers to the product slightly soluble or insoluble )

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

PRI 724 | PRI724

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Protocol Information

PRI-724 (orb1223869)

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% DMSO +
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Available Sizes

Select a size below

2 mg
$ 90.00
5 mg
$ 120.00
10 mg
$ 190.00
25 mg
$ 370.00
50 mg
$ 500.00
100 mg
$ 710.00
500 mg
$ 1,510.00