Prasugrel Hydrochloride

SKU: orb1300316

Description

Prasugrel Hydrochloride

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 389574-19-0
• MW: 409.9
• Purity: 99.79%
• Formula: C₂₀H₂₀FNO₃S·HCl
• SMILES: Cl.CC(=O)Oc1cc2CN(CCc2s1)C(C(=O)C1CC1)c1ccccc1F
• Target: P2Y Receptor
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.88 mM);DMSO:43 mg/mL (104.9 mM);Ethanol:9 mg/mL (21.96 mM)

Bioactivity

• Target IC50:
  Platelet:1.8 μM.
• In Vivo:
  Prasugrel significantly inhibits arterio-venous (AV) shunt and electrically induced arterial thrombosis in single dose ranges of 0.3 to 3 mg/kg and of 0.3 and 1 mg/kg/day for multiple doses. These doses are similar to doses with inhibition of platelet activation via P2Y12 receptors, suggesting that the protective effects of prasugrel in these cerebral infarction and peripheral arterial occlusive disease models reflect P2Y12 inhibitions on platelets by prasugrel's active metabolite. Prasugrel also significantly prevents progression of peripheral vascular lesions.

Storage & Handling

• Storage: keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Prasugrel, Prasugrel HCl, Prasugrel Hydrochloride, platelet, P2YReceptor, P2Y12, P2Y Receptor, P2Y, PCR 4099, PCR 4099 (hydrochloride), PCR4099, PCR-4099, LY 640315 Hydrochloride, LY-640315, LY640315 Hydrochloride, LY-640315 Hydrochloride, LY640315, Effient, Effient Hydrochloride, antiplatelet, active, aggregation

Compound Identifiers

PubChem CID

10158453