Pranoprofen

SKU: orb1224801

Description

Pranoprofen is a PGE2 inhibitor with IC50 of 7.5 μM.(In Vitro):Pranoprofen (pretreatment for 1 h; 1 mM) has an inhibitory effect against ER stress-induced GRP78 and CHOP expression in glial cells.Pranoprofen (5-25 μM; 24 h) dose-dependently enhances Dicer expression. Additionally, Pranoprofen at 5 μM enhances H2O2 (800 μM)-induced Dicer expression in FHC cells.(In Vivo):Pranoprofen (oral administration; 4 mg/kg/16 mg/kg; 9 days) rescues Dicer expression in inflamed colon tissues, alleviates colitis and prevents colitis-associated colon cancers in C57BL/6 mice.Dicer is a key component of the RNA interference pathway and is essential for the biogenesis of miRNAs and siRNAs.

Key Properties

• CAS Number: 52549-17-4
• MW: 255.28
• Purity: >98% (HPLC)
• Formula: C₁₅H₁₃NO₃
• SMILES: CC(C1=CC(CC2=CC=CN=C2O3)=C3C=C1)C(O)=O
• Target: Prostaglandin Receptor
• Solubility: Ethanol: 6 mg/mL (23.5 mM); DMSO: 51 mg/mL (199.78 mM)

Bioactivity

• In Vivo:
  Pranoprofen (oral administration; 4 mg/kg/16 mg/kg; 9 days) rescues Dicer expression in inflamed colon tissues, alleviates colitis and prevents colitis-associated colon cancers in C57BL/6 mice. Dicer is a key component of the RNA interference pathway and is essential for the biogenesis of miRNAs and siRNAs. Animal model: DSS-induced acute colitis in C57BL/6 mice. Dosage: 4 mg/kg; 16 mg/kg. Administration: Oral administration; 4 mg/kg/16 mg/kg; 9 days. Result: Alleviated inflammation in DSS-induced acute colitis.
• In Vitro:
  Pranoprofen (pretreatment for 1 h; 1 mM) has an inhibitory effect against ER stress-induced GRP78 and CHOP expression in glial cells. Pranoprofen (5-25 μM; 24 h) dose-dependently enhances Dicer expression. Additionally, Pranoprofen at 5 μM enhances H2O2 (800 μM)-induced Dicer expression in FHC cells.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Pyranoprofen | Y 8004

Quick Database Links

Gene Symbol

Prostaglandin Receptor