Pramipexole 2HCl Monohydrate

SKU: orb1222570

Description

Pramipexole Dihydrochloride is a D2/3 agonist. It acts by reducing mitochondrial ROS production and inhibiting the activation of apoptotic pathways.(In Vitro):Pramipexole dihydrochloride hydrate shows a low binding affinity for D1-type receptor, with an IC50 of >50,000 nM.Pramipexole dihydrochloride hydrate (0.01-10 μM; 72 hours) produces dose-dependent increases of dendritic arborization and soma size.Pramipexole dihydrochloride hydrate attenuates levodopa-induced toxicity in mesencephalic cultures.(In Vivo):Pramipexole dihydrochloride hydrate (0.25-1 mg/kg; i.p.) significantly reduces the infarction volume in animals.Pramipexole dihydrochloride hydrate improves neurological recovery.Pramipexole dihydrochloride hydrate prevents ischemic cell death via mitochondrial pathways in ischemic stroke.

Key Properties

• CAS Number: 191217-81-9
• MW: 302.26
• Purity: >98% (HPLC)
• Formula: C₁₀H₁₇N₃S·2HCl·H₂O
• SMILES: O.Cl.CCCN[C@H]1CCc2c(C1)sc(N)n2.Cl
• Target: D2S|D2L|D3|D4
• Solubility: In Vitro: H2O : 100 mg/mL (330.84 mM)

Bioactivity

• In Vivo:
  Pramipexole dihydrochloride hydrate (0.25-1 mg/kg; i.p.) significantly reduces the infarction volume in animals. Pramipexole dihydrochloride hydrate improves neurological recovery. Pramipexole dihydrochloride hydrate prevents ischemic cell death via mitochondrial pathways in ischemic stroke. Animal model: Male Wistar rats weighing 250-300 g (16-18 weeks old). Dosage: 0.25 mg/kg, 1 mg/kg. Administration: Intraperitoneal injection. Result: Decreased infarction volume as compared to tMCAO (transient middle cerebral artery occlusion)-only animals.
• In Vitro:
  Pramipexole dihydrochloride hydrate shows a low binding affinity for D1-type receptor, with an IC50 of >50, 000 nM. Pramipexole dihydrochloride hydrate (0.01-10 μM; 72 hours) produces dose-dependent increases of dendritic arborization and soma size. Pramipexole dihydrochloride hydrate attenuates levodopa-induced toxicity in mesencephalic cultures.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Pramipexole Dihydrochloride Monohydrate | Pramipexole Dihydrochloride

Quick Database Links

Gene Symbol

D2S|D2L|D3|D4