Praliciguat

SKU: orb1307856

Description

Praliciguat (IW-1973) is an orally bioavailable stimulator of soluble guanylate cyclase (sGC), demonstrating an EC50 of 197 nM in HEK-293 cells. It functions by enhancing nitric oxide signaling, leading to vasodilation, and is utilized in cardiovascular and metabolic disease research in both in vitro and in vivo models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1628730-49-3
• MW: 534.36
• Purity: 99.05% (May vary between batches)
• Formula: C₂₁H₁₄F₈N₆O₂
• SMILES: OC(CNc1nc(ncc1F)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1)(C(F)(F)F)C(F)(F)F
• Target: Guanylate cyclase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (9.36 mM);DMSO:245 mg/mL (458.49 mM)

Bioactivity

• Target IC50:
  sGC:（EC50）197 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

sGC, Praliciguat, IW 1973, IW1973, IW-1973, inhibit, Inhibitor, Guanylate cyclase, Guanylate Cyclase, Guanylatecyclase

Compound Identifiers

PubChem CID

86269973