Pralatrexate, (R)-

• Catalog Number: orb1701775
• Category: Small Molecules
• Description: Pralatrexate, (R)-
• CAS Number: 1320211-70-8
• Purity: 98%
• MW: 477.47
• SMILES: NC=1C2=C(N=CC(C[C@@H](CC#C)C3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)N=C(N)N1
• Formula: C₂₃H₂₃N₇O₅
• Biological Activity: Pralatrexate, (R)- is a folate analog dihydrofolate reductase (DHFR) inhibitor exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive activities. Pralatrexate selectively enters cells expressing RFC-1; intracellularly, this agent is highly polyglutamylation and competes for the folate binding site of DHFR, blocking tetrahydrofolate synthesis.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.