Praeruptorin B

SKU: orb1689932

Description

Praeruptorin B (Praeruptorin D) is a natural SREBP inhibitor derived from Peucedanum roots. It suppresses renal cancer cell metastasis by downregulating CTSC and CTSV expression and is also utilized in osteoporosis research. Its biological activity has been demonstrated in in vitro cellular studies.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 73069-28-0
• MW: 426.46
• Purity: 99.91% (May vary between batches)
• Formula: C₂₄H₂₆O₇
• SMILES: O(C(/C(=C\C)/C)=O)[C@H]1C=2C3=C(C=CC2OC(C)(C)[C@H]1OC(/C(=C\C)/C)=O)C=CC(=O)O3
• Target: NPC1L1
• Solubility: DMSO:20 mg/mL (46.9 mM);10% DMSO+90% Corn Oil:2 mg/mL (4.69 mM)

Bioactivity

• In Vivo:
  Mice treated with 50 mg/kg Praeruptorin B weighed significantly less than those treated with the vector, although they were still heavier than mice fed regular chow, suggesting that Praeruptorin B ameliorates diet-induced obesity (DIO). Staining results showed that Praeruptorin B-treated mice exhibited less lipid accumulation than vector-treated mice. Elevated fasting blood glucose and insulin levels in high-fat diet-fed mice were significantly reduced by Praeruptorin B. The results showed that the elevated fasting blood glucose and insulin levels in Praeruptorin B-treated mice were significantly reduced.
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• In Vitro:
  Praeruptorin B inhibited the activity of SREBPs and reduced intracellular lipid levels, and significantly down-regulated the expression of SREBP-1c and SREBP-2.Praeruptorin B potently reduced SRE-luciferase activity and the effect was dose-dependent.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

81740-07-0, inhibit, Fatty Acid Synthase (FASN), Inhibitor, Praeruptorin D, Praeruptorin B, SREBPs, T6S1423

Compound Identifiers

PubChem CID

25717254