(±)-Praeruptorin A

SKU: orb1302322

Description

Praeruptorin A is a bioactive small molecule that inhibits osteoclast formation and bone resorption by targeting Ca²⁺/calmodulin and suppressing the p38/Akt-c-Fos-NFATc1 and CaMKIV/calcineurin-NFATc1 signaling pathways. It also upregulates MRP2 via CAR, indicating potential herb-drug interactions, making it a valuable tool for bone metabolism and drug transport research.

Research Area

Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 73069-25-7
• MW: 386.40
• Purity: 98.90%
• Formula: C₂₁H₂₂O₇
• SMILES: C\C=C(\C)C(=O)O[C@@H]1[C@H](OC(C)=O)c2c(OC1(C)C)ccc1ccc(=O)oc21
• Target: p38 MAPK,Calcium Channel,Akt
• Solubility: Ethanol:Soluble;DMSO:70.00 mg/mL (181.16 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2.00 mg/mL (5.18 mM);Pyridine, Methanol, etc.:Soluble

Storage & Handling

• Storage: store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Praeruptorin A, p38, p38 MAPK, p38MAPK, CalciumChannel, Calcium Channel, Ca channels, Ca2+ channels, (-)-Praeruptorin A, (±)Praeruptorin A, (±)-Praeruptorin A, (±) Praeruptorin A, Akt, Inhibitor, inhibit

Compound Identifiers

PubChem CID

9821539