PR-924

SKU: orb1988978

Description

PR-924 is a potent, selective, and covalent inhibitor of the immunoproteasome subunit LMP-7, demonstrating an IC50 of 22 nM. It induces apoptosis and suppresses proliferation in multiple myeloma cells in vitro and has shown promising antitumor efficacy in relevant in vivo models.

Research Area

Cell Biology, Protein Biochemistry

Key Properties

• CAS Number: 1416709-79-9
• MW: 618.72
• Formula: C₃₇H₃₈N₄O₅
• SMILES: C[C@@H](NC(=O)C1=C(C)c2ccccc2C1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)[C@@]1(C)CO1
• Target: Apoptosis,Proteasome

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

92135659