PQR530

SKU: orb1307857

Description

PQR530

Research Area

Signal Transduction

Key Properties

• CAS Number: 1927857-61-1
• MW: 407.42
• Purity: 99.78%
• Formula: C₁₈H₂₃F₂N₇O₂
• SMILES: C[C@H]1COCCN1c1nc(nc(n1)-c1cnc(N)cc1C(F)F)N1CCOCC1
• Target: mTOR,PI3K
• Solubility: DMSO:25 mg/mL (61.36 mM)

Bioactivity

• Target IC50:
  mTOR:0.33 nM (Kd)|PI3Kγ:10 nM (Kd)|PI3Kα:0.84 nM (Kd)|PI3Kβ:6.1 nM (Kd)|PI3KC2β:100 nM (Kd)|PI3Kδ:11 nM (Kd)
• In Vitro:
  PQR-530 inhibits All PI3K isoforms and mTOR complexes C1/2 potently and selectively. PQR-530 inhibits protein kinase B (PKB, pSer473) and ribosomal protein S6 (pS6, pSer235/236) phosphorylation IC50 0.07 μM in A2058 melanoma cells). PQR-530 displays inhibitory activity agains the growth of 44 cancer cell lines (mean GI50: 426 nM.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Phosphoinositide 3-kinase, PI3K, PQR 530, PQR530, PQR-530, Mammalian target of Rapamycin, Inhibitor, inhibit, mTORC1, mTORC2, mTOR

Compound Identifiers

PubChem CID

121334433