PPL agonist-1

• Catalog Number: orb2814432
• Category: Small Molecules
• Description: PPL agonist-1 (Compound I-3) is a highly selective agonist of Periplakin (PPL) that raises cAMP levels by modulating PPL, enhancing MITF expression, and consequently promoting melanin synthesis. Additionally, it stimulates melanin production by regulating tryptophan metabolism. Compared to Ruxolitinib, PPL agonist-1 demonstrates superior effectiveness and holds potential for vitiligo research.
• MW: 507.54
• CAS Number: 3040997-52-9
• Formula: C₂₅H₂₂FN₅O₄S
• SMILES: CC=1C=C(C2=CC=C([C@@H](NC=3N=C(NS(=O)(=O)C4=CC(N(=O)=O)=CC=C4)C=CN3)C)C=C2)C=CC1F
• Storage: -20°C
• Note: For research use only