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PPARγ agonist-21

SKU: orb3175001

Description

PPARγagonist-21 (Compound 9a) is a PPARγ agonist with an EC50 of 3.12 μM. It inhibits NF-κB by activating PPAR-γ and reduces the assembly of the NLRP3 inflammasome. PPARγagonist-21 blocks interactions between NLRP3-ASC and NLRP3-NEK7, alleviating the severity of gouty arthritis.

Research Area

Immunology & Inflammation, Metabolism Research, Molecular Biology, Signal Transduction

Images & Validation

Key Properties

TargetNF-κB,PPAR,MAPK,NOD-like Receptor (NLR)

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information