PPARδ agonist 13

SKU: orb3210127

Description

PPARδ agonist13 is a potent, selective, and orally active PPARδ agonist with an EC50 value of 0.50 nM. It binds to the ligand binding pocket of PPARδ, enhancing the expression of PPARδ target genes. This compound inhibits kidney fibroblast activation, restores fatty acid oxidation, and reduces TGF-β1-induced kidney fibroblast activation. In a unilateral ureteral obstruction mouse model, it demonstrates anti-renal fibrosis effects. PPARδ agonist13 is applicable in research related to renal fibrosis.

Key Properties

• CAS Number: 3056618-93-7
• MW: 521.48
• Formula: C₂₇H₂₅F₃N₂NaO₄
• SMILES: [Na].O=C(O)CCCCCOC=1C=CC=CC1CN2C(=NC=3C=CC=CC32)C=4C=CC(OC(F)(F)F)=CC4
• Target: PPAR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PPAR